Real Madrid v Sevilla

The No. 3 Notre Dame Fighting Irish renew their in-state rivalry with Purdue at Ross-Ade Stadium after opening the season with three convincing victories. Can Ryan Browne and Purdue's explosive passing game score enough against Notre Dame to keep the Boilermakers inside four touchdowns? Check out this Notre Dame vs. Purdue prediction and best bet for Saturday, September 26.

The Illinois Fighting Illini begin Big Ten play with one of the toughest assignments in the country as they travel to Columbus to face No. 7 Ohio State. Can Katin Houser and an Illinois offense coming off its best performance of the season generate enough scoring to stay within four touchdowns against Julian Sayin and the Buckeyes? Check out this Illinois vs. Ohio State prediction and best bet for Saturday, September 26.

The No. 1 Texas Longhorns open SEC play with their first true road test of the season against No. 14 Tennessee in one of the biggest games of Week 4 at Neyland Stadium. Can Faizon Brandon, Daune Morris and the Volunteers take advantage of a Texas offense that looked vulnerable against UTSA while feeding off one of the toughest home environments in college football? Check out this Texas vs. Tennessee prediction and best bet for Saturday, September 26.

The Wake Forest Demon Deacons head back on the road for an ACC matchup against No. 16 Louisville after hanging around with Miami deep into the fourth quarter. Can Gio Lopez and the Demon Deacons create enough explosive offense to stay within two touchdowns against a Cardinals team coming off a ranked victory over SMU? Check out this Wake Forest vs. Louisville prediction and best bet for Saturday, September 26.

The Clemson Tigers make their first West Coast conference trip for a Friday night ACC matchup against California at Memorial Stadium. Can Tait Reynolds and Clemson's improving rushing attack handle the cross-country setting against Jaron-Keawe Sagapolutele and a Cal defense that has been creating turnovers at one of the highest rates in the country? Check out this Clemson vs. California prediction and best bet for Friday, September 25.

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