Fresno State opens its 2026 season with a major test against No. 14 USC under the Friday night lights at the Coliseum. The Trojans already have one dominant performance behind them, but Fresno State returns the core of an excellent defense and brings a physical style capable of making this matchup more competitive than the spread suggests. Check out this Fresno State vs. USC prediction and best bet for Friday, September 4.

Miami heads across the country for its 2026 season opener against a Stanford team that already survived a difficult Week 0 test at home. The Hurricanes remain loaded after reaching last season's national championship game, but significant roster turnover and a 24.5-point road spread create a much higher bar than simply winning. Check out this Miami vs. Stanford prediction and best bet for Friday, September 4.

Toledo and Michigan State open their 2026 seasons Friday night with both programs beginning new coaching eras. Mike Jacobs takes over a Rockets team coming off eight wins, while Pat Fitzgerald inherits a Michigan State roster looking for a major rebound after a difficult Big Ten campaign. Check out this Toledo vs. Michigan State prediction and best bet for Friday, September 4.

Ben Shelton and Denis Shapovalov meet Friday night in a blockbuster third-round matchup between two explosive left-handers. Shelton has dropped a set in both of his US Open matches so far, but his serve has become increasingly difficult to touch and the head-to-head history against Shapovalov is about as convincing as it gets.

LIU faces another difficult road assignment Friday night when the Sharks travel to Lawrence to open Kansas' 2026 season. The Jayhawks have overwhelming advantages in size and depth, but a new quarterback and significant offensive turnover make the scoring pace more interesting than the massive point spread. Check out this LIU vs. Kansas prediction and best bet for Friday, September 4.

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