Read our Anderlecht vs Lyon prediction with betting tips, probable lineups and odds analysis as both teams clash in an exciting Europa League fixture.
Anderlecht vs Lyon Match Summary
Competition | UEFA Europa League |
|---|---|
Match Date | Wednesday 16 September 2026 |
Match Time | 20:00 UK time |
Venue (City, Stadium) | Lotto Park, Brussels |
Broadcast (TV / Streaming / Radio / Bookmaker Streaming) | TNT Sports 4, TNT Sport Extra (UK) |
Anderlecht host Lyon at Lotto Park in Brussels on Wednesday night to kick off the Europa League league phase, and this match has the look of an open, goal-laden opener.
The Belgian side arrive unbeaten in three games after Tawfik Bentayeb's goal just before half-time saw off Mechelen, though their domestic campaign has been a mixed bag.
Lyon dropped into this competition after failing to beat Fenerbahce to a Champions League berth. They are unbeaten in Ligue 1 but have won only two of four outings.
There is history here too. Anderlecht have seen over 2.5 goals in each of their last four meetings with Lyon in all competitions, which sets the tone nicely.
Anderlecht vs Lyon Form
Anderlecht are ticking over. They are unbeaten in three, capped by Bentayeb's decisive strike against Mechelen, but the domestic start has been patchy rather than convincing. They sit high in the form rankings and, importantly, a win for them in the Win Market would have landed six times in their last ten outings.
Lyon are unbeaten after four Ligue 1 games but have only two wins, dropping points against Le Havre and Paris FC. They missed out on the Champions League after failing to see off Fenerbahce, and a win for them would have landed four times in their last ten matches.
Anderlecht vs Lyon Lineups & Team News
Injuries & Suspensions
Anderlecht: L. Hey (Injured/out), M. Stroeykens (Injured/out), K. Sardella (Injured/out), G. Biancone (Injured/doubtful)
Lyon: None reported
Anderlecht
Lucas Hey is one of three confirmed absentees for the hosts, and there is a further worry over centre-back Giulian Biancone, who is a doubt after picking up a knock against Mechelen. Andrew Omobamidele and Romeo Amané could both come into the side on Wednesday.
Lyon
It is a clean bill of health for Lyon, who travel to Belgium with a fully fit squad for gameweek one. The visitors could hand midfielder Tanner Tessmann a start on Wednesday night.
Anderlecht vs Lyon Predicted Lineup
Anderlecht
Formation: 4-4-2
Predicted Starting Lineup: Coosemans; Maamar, Pétrot, Omobamidele, Augustinsson; Winkler, Kana, Amané, Antman; Sikan, Bentayeb
Lyon
Formation: 4-2-3-1
Predicted Starting Lineup: Greif; Athekame, Niakhaté, Bacher, Vinícius; Morton, Tessmann; Nuamah, Tolisso, Sulc; Openda
Anderlecht vs Lyon Key Stats & Match Facts
Anderlecht have seen over 2.5 goals in their last four matches against Lyon in all competitions.
Anderlecht come into this one unbeaten in three games across all competitions.
Lyon are unbeaten in Ligue 1 this season but have won just two of their four outings.
An Anderlecht win in the Win Market would have landed six times in their last ten matches.
A Lyon win would have landed four times in their last ten matches.
Anderlecht vs Lyon Prediction & Best Bets
Our prediction: This has the feel of an open, high-scoring opener, with a projected 3.18 total goals on the cards. Lyon shade it on the numbers, edging a 1.68 to 1.51 verdict, and our Anderlecht vs Lyon prediction is for the visitors to nick it in a game with goals at both ends.
Best Bets
Over 2.5 goals in the Total Goals Over/Under market. Every one of the last four meetings between these two has cleared this line, and the projections point to 3.18 total goals here. That is a trend well worth leaning on.
Lyon to win in the Win Market. Lyon land as match favourites with a 41.9% implied probability and a projected 1.68 to 1.51 win. A fully fit travelling squad with clear quality makes them a solid pick to come out on top.
Anderlecht vs Lyon Bet Builder
This four-leg selection combines Lyon to win, Loïs Openda to score anytime, both teams to score, and Tristan Degreef to be shown a card in Brussels on Wednesday night.
Lyon hold the edge on the projections, with a 1.68 to 1.51 win forecast pointing to the visitors taking all three points at Lotto Park.
Openda is the spearhead of the Lyon attack and the man Anderlecht are building their whole plan around stopping. If he shakes off that attention, he is a strong shout to find the net.
Both teams to score fits the picture perfectly. All four recent meetings between these sides have flown past 2.5 goals, and both attacks look capable of chipping in here.
Degreef rounds off the ticket in the cards market, a sensible inclusion given the disciplinary potential that tends to come with a keenly contested continental opener.
Across the board, the combined price on this bet builder tops out at 18/1 and drops as low as 14/1 at the other end of the market.
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Bet builder odds correct at time of publishing.
Anderlecht vs Lyon Talking Points
The big question is whether Anderlecht can handle Loïs Openda. The hosts' entire tactical plan is built around collectively neutralising the Lyon forward as the principal attacking threat, and stopping him could decide the outcome. Get it right and Anderlecht have a platform; get it wrong and Lyon's edge on the numbers looks well founded. With four straight meetings between these two clearing 2.5 goals in all competitions, though, expect chances at both ends whichever way the plan goes.
Anderlecht vs Lyon Predictions FAQs
When is the Anderlecht vs Lyon Europa League game?
The match takes place on Wednesday 16 September 2026, kicking off at 20:00 UK time.
Where is Anderlecht vs Lyon being played?
The match is being played at Lotto Park in Brussels.
Where can I watch Anderlecht vs Lyon?
The fixture is televised live on TNT Sports 4 and TNT Sport Extra in the UK.
What competition is Anderlecht vs Lyon in?
Anderlecht vs Lyon is a UEFA Europa League match.
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