TSG Hoffenheim vs Lyon: explore probable lineups, prediction, bet builder tips, match odds and best bets for this Europa League clash before kick-off.
TSG Hoffenheim vs Lyon Match Summary
Competition | Europa League |
|---|---|
Match Date | Thursday 22 October 2026 |
Match Time | 20:00 UK time |
Venue (City, Stadium) | Sinsheim, SNP Arena |
Broadcast (TV / Streaming / Radio / Bookmaker Streaming) | TNT Sport Extra (UK) |
Hoffenheim host Lyon at the SNP Arena in the Europa League, and the TSG Hoffenheim vs Lyon prediction comes down to whether the hosts can finally get off the mark.
Christian Ilzer's side sit 30th without a point after two European defeats. There is real attacking quality in this squad, but it badly needs something to show for it.
Lyon arrive eighth with six points from six, although losing Loïs Openda, Nicolás Tagliafico and Mohamed Ouédraogo leaves Paulo Fonseca short at left-back and in attack.
Hoffenheim have drawn their last three matches against Lyon in all competitions, and all of those meetings saw over 2.5 goals. Do not expect a cagey evening.
TSG Hoffenheim vs Lyon Form
Hoffenheim have lost both of their Europa League outings, the latest a 3-2 home defeat to Beşiktaş in which Fisnik Asllani and Koki Machida scored. The domestic response was a 2-1 win over Borussia Mönchengladbach at the weekend, ending a losing run in all competitions. The attack carries a threat, but the defending has been messy.
Lyon are flying in Europe, beating Crystal Palace 3-2 last time out with Corentin Tolisso and Ernest Nuamah among the scorers. Domestically they came from behind to beat Nice, and Paulo Fonseca's side have lost just once in nine competitive fixtures. Keito Nakamura is the creative spark, setting up two against Palace.
TSG Hoffenheim vs Lyon Lineups & Team News
Injuries & Suspensions
TSG Hoffenheim: Albian Hajdari (Injured/out), Patrick Wimmer (Injured/out), Nathan De Cat (Injured/out)
Lyon: Loïs Openda (Injured/out), Mohamed Ouédraogo (Injured/out), Nicolás Tagliafico (Injured/out)
TSG Hoffenheim
The TSG Hoffenheim vs Lyon lineups are not confirmed yet, so this is the probable XI. Ilzer is without De Cat, Hajdari and Wimmer but otherwise has a strong core available, with Oliver Baumann in goal. Andrej Kramarić starts on the right of a midfield four and remains one of Hoffenheim's most important creative players. Asllani partners Adam Hložek up front and has contributed directly to a second-half goal in each of the last two home matches.
Lyon
Fonseca's probable XI has Dominik Greif in goal, with Tolisso, Tyler Morton and Noah Nartey forming the engine room behind Khalis Merah. Nakamura partners Nuamah in attack and leads all players in this season's Europa League for expected assists. At the back, Lyon have conceded only six goals across their last six matches.
TSG Hoffenheim vs Lyon Predicted Lineup
TSG Hoffenheim
Formation: 4-4-2 (probable)
Predicted Starting Lineup: Oliver Baumann; Vladimír Coufal, Ozan Kabak, Koki Machida, Bernardo; Andrej Kramarić, Wouter Burger, Leon Avdullahu, Adam Daghim; Adam Hložek, Fisnik Asllani
Lyon
Formation: 4-3-1-2 (probable)
Predicted Starting Lineup: Dominik Greif; Zachary Athekame, Felix Bacher, Ruben Kluivert, Abner; Noah Nartey, Tyler Morton, Corentin Tolisso; Khalis Merah; Ernest Nuamah, Keito Nakamura
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TSG Hoffenheim vs Lyon Key Stats & Match Facts
Hoffenheim have drawn their last 3 matches against Lyon in all competitions.
Hoffenheim have seen over 2.5 goals in their last 3 matches against Lyon in all competitions.
Hoffenheim have scored at least 2 goals in their last 3 matches against Lyon in all competitions.
Lyon have scored at least 2 goals in their last 3 matches against Hoffenheim in all competitions.
TSG Hoffenheim vs Lyon Prediction & Best Bets
Our prediction: Hoffenheim to edge an open game with goals at both ends. Lyon bring the better form, but they are short of bodies in attack and the hosts carry the higher implied probability of victory here, ahead of both Lyon and the draw. In the TSG Hoffenheim vs Lyon betting odds, the home win is 21/20 with Betfred, and that price has shortened since the market opened.
Best Bets
Over 2.5 goals in the Total Goals Over/Under market. Hoffenheim and Lyon have drawn their last three meetings, and each of those had at least 2.5 goals. That pattern fits the way this fixture tends to go, and Hoffenheim have already shipped five goals in their Europa League outings so far. Lyon's front two are not the sort to let that leak go unpunished.
TSG Hoffenheim to win in the Win Market. They are the home side's best hope of a first European points haul, up against a Lyon side missing Openda. The hosts carry the higher implied probability of the three outcomes here, and the money has come their way since the opening show. With Openda, Tagliafico and Ouédraogo all out, Fonseca is light at left-back and up front.
TSG Hoffenheim vs Lyon Bet Builder
Our TSG Hoffenheim vs Lyon bet builder tips combine a home win, Andrej Kramarić to score anytime, both teams to score and Ozan Kabak to be shown a card.
Hoffenheim to win: the home price has come in since the market opened, and Lyon's attacking options are thinner without Openda. The hosts have to start picking up points somewhere.
Kramarić to score anytime: he is Hoffenheim's key attacking focal point and the player most likely to unlock Lyon's back four from his role on the right.
Both teams to score: seven of Hoffenheim's last eight matches have seen both sides score, and Nakamura and Nuamah carry more than enough threat to keep that run going.
Kabak to be shown a card: the centre-back faces a busy night trying to keep tabs on Nakamura, and he is not short of history for picking up bookings in games like this.
At the time of writing, this bet builder pays a best price of 14/1 and is as short as 23/2 elsewhere.
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Bet builder odds correct at time of publishing.
TSG Hoffenheim vs Lyon Talking Points
The biggest obstacle to our TSG Hoffenheim vs Lyon best bets is Lyon's record on their travels. They have lost only two of their last 19 Europa League away matches, so this is no formality for the hosts. Fonseca wants to keep his perfect European start going, while Ilzer is chasing his side's first points of the campaign, and that desperation should make Hoffenheim direct and aggressive from kick-off. If Kramarić gets on the ball in the right areas, the hosts have the quality to make Lyon's missing trio count.
TSG Hoffenheim vs Lyon Predictions FAQs
When is the TSG Hoffenheim vs Lyon Europa League game?
The match kicks off at 20:00 UK time on Thursday 22 October 2026.
Where is TSG Hoffenheim vs Lyon being played?
The match is being played at SNP Arena.
Where can I watch TSG Hoffenheim vs Lyon?
In the UK, the match is listed on TNT Sport Extra.
What competition is TSG Hoffenheim vs Lyon in?
The match is a Europa League fixture in the 2026/2027 season.
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