The Florida International Panthers head to Jacksonville for an important Conference USA matchup against a Jacksonville State Gamecocks team riding a three-game winning streak. Can Caden Creel and the Gamecocks’ dual-threat rushing attack solve an FIU defense that has allowed only six points over its last two games? Check out this FIU vs. Jacksonville State prediction and best bet for Tuesday, October 13.

The Delaware Fightin’ Blue Hens travel to Murfreesboro for a Tuesday night Conference USA matchup against the Middle Tennessee Blue Raiders with both teams looking for their first league win. Can Delaware rediscover the offensive efficiency that carried it earlier in the season against a Middle Tennessee defense that has struggled badly over its last two games? Check out this Delaware vs. Middle Tennessee prediction and best bet for Tuesday, October 13.

The Buffalo Bills visit the Los Angeles Rams on Monday Night Football in a potential Super Bowl preview at SoFi Stadium. Can Davante Adams, James Cook and Josh Allen swing a matchup featuring two of the NFL's most dangerous offenses? Check out this Bills vs. Rams same game parlay and best bet for Monday, October 12.

The Buffalo Bills visit the Los Angeles Rams on Monday Night Football in a potential shootout between two offenses capable of producing points in bunches at SoFi Stadium. Can Josh Allen, Matthew Stafford and their red-zone playmakers turn another high-total matchup into a touchdown-heavy night? Check out these Bills vs. Rams 5 anytime touchdown scorer picks for Monday, October 12.

The Buffalo Bills visit the Los Angeles Rams on Monday Night Football to close out Week 5 at SoFi Stadium. Can Matthew Stafford and James Cook make the difference in a matchup featuring two offenses capable of creating explosive plays? Check out these Bills vs. Rams 5 best bets for Monday, October 12.

Patrick Mahomes has taken complete control of the NFL Comeback Player of the Year race after returning from major knee surgery to lead Kansas City to a 4-0 start. Kyler Murray remains the closest challenger after guiding Minnesota to an unbeaten start of its own, while Michael Penix Jr. and Kirk Cousins sit well behind the favorite. Check out the latest NFL Comeback Player of the Year odds entering Week 6.

David Bailey has surged to the top of the Defensive Rookie of the Year market after a three-sack breakout, while Jacob Rodriguez and Arvell Reese remain close behind with elite tackle production. Sonny Styles continues to build a strong all-around résumé, while longer shots Mansoor Delane and Caleb Downs still have paths to climb. Check out the latest NFL Defensive Rookie of the Year odds entering Week 6.

Denzel Boston and Jeremiyah Love have separated themselves at the top of the Offensive Rookie of the Year market, while Carnell Tate remains within striking distance despite Tennessee's disastrous start. Injuries could also reshape the race quickly, particularly with KC Concepcion entering concussion protocol. Check out the latest NFL Offensive Rookie of the Year odds entering Week 6.

The 49ers stayed unbeaten with another statement win, Buffalo bounced back by beating the Rams and Jacksonville continued its rapid rise, while Philadelphia, New Orleans and the Chargers kept sliding. Check out the latest NFL Power Rankings entering Week 6 of the 2026 season.

The Rams, Bills and 49ers are now separated by almost nothing at the top of the Super Bowl market, with all three sitting around the +700 to +800 range. Baltimore and Kansas City remain close behind, while Jacksonville continues to gain respect after a 4-1 start. Check out the latest Super Bowl LXI odds entering Week 6 of the 2026 NFL season.