Southern Methodist Mustangs at Louisville Cardinals

The Detroit Lions visit the Buffalo Bills on Thursday Night Football as Buffalo opens the new Highmark Stadium. Can Josh Allen, Dalton Kincaid and Jameson Williams deliver in a matchup built for explosive offense? Check out this Lions vs. Bills same game parlay and best bet for Thursday, September 17.

The Syracuse Orange travel to face the Pittsburgh Panthers under the Thursday night lights for an early ACC rivalry matchup at Acrisure Stadium. Can Steve Angeli clean up the turnovers and keep Syracuse competitive against Mason Heintschel and a Pitt defense that has opened the season in strong form? Check out this Syracuse vs. Pittsburgh prediction and best bet for Thursday, September 17.

The Detroit Lions visit the Buffalo Bills on Thursday Night Football for Buffalo’s first regular-season game at the new Highmark Stadium, with the total climbing to a massive 54.5 points. Can Josh Allen, Jared Goff and two loaded groups of playmakers turn one of the season’s highest totals into another primetime shootout? Check out these Lions vs. Bills 5 anytime touchdown scorer picks for Thursday, September 17.

Get our Besiktas vs Marseille prediction, projected lineups, and top betting picks for this Europa League game. Explore Same Game Parlay picks and odds.

Lillestrom vs Torreense prediction, lineups, and betting picks for Thursday's Europa League game. Explore odds analysis and Same Game Parlay insights now.

Who was the DraftKings King of the Endzone on Thursday Night Football? View the $2M winner payout breakdown and claim $200 in bonus bets for NFL Week 2.

Claim FanDuel's 7-Point Early Win promo for Bills vs Lions! Get paid out instantly if your team leads by 7+ points + get up to $350 in bonus bets.

Claim DraftKings' $2M King of the Endzone promo for Lions vs Bills! Plus, new users get $200 in guaranteed bonus bets on Thursday Night Football.

Bet $1 on 1+ point scored in Bills vs Lions to get $100 in bonus bets! Claim the new DraftKings promo code for Thursday Night Football.

Claim Polymarket promo code CHECK for Lions vs Bills! Deposit $10 to unlock a $50 trading bonus for Thursday Night Football on Prime Video.