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TCU travels to Tucson for a Friday night Big 12 showdown against No. 22 Arizona, with the Wildcats looking to rebound from their second defeat of the season while the Horned Frogs fight for bowl eligibility. Can Noah Fifita and Isaiah Mizell overcome one of the conference's strongest passing defenses and restore Arizona's offensive momentum? Check out this TCU vs. Arizona prediction and best bet for Friday, November 6.

No. 22 New Mexico travels to Reno for a Friday night Mountain West showdown against Nevada, with the Lobos looking to preserve their undefeated conference record and strengthen their championship position. Can Toa Fa'avae and Scottre Humphrey overcome the Wolf Pack's defensive resistance while New Mexico's dominant front limits Nevada's rushing attack? Check out this New Mexico vs. Nevada prediction and best bet for Friday, November 6.

Nebraska travels to Champaign for a Friday night Big Ten showdown against Illinois, with both programs entering at 5-3 and looking to strengthen their bowl and conference positioning. Can Katin Houser and the surging Fighting Illini extend their three-game winning streak against Anthony Colandrea and a Cornhuskers defense that has been among the nation's best? Check out this Nebraska vs. Illinois prediction and best bet for Friday, November 6.

South Florida travels to Greenville for a Friday night American Conference showdown against East Carolina, with both programs looking to remain competitive in a crowded conference championship race. Can Michael Van Buren and the Bulls overcome their recent offensive struggles against Mitch Griffis and a Pirates defense gaining momentum at home? Check out this South Florida vs. East Carolina prediction and best bet for Friday, November 6.

Virginia Tech travels to Dallas for a Friday night ACC showdown against SMU, with both programs entering at 6-2 and looking to strengthen their conference championship hopes. Can Kevin Jennings and the Mustangs overcome Ethan Grunkemeyer and a Hokies defense that ranks among the nation's leaders in sacks and tackles for loss? Check out this Virginia Tech vs. SMU prediction and best bet for Friday, November 6.

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