Arizona Cardinals vs. Minnesota Vikings Week 2 Betting Preview, Odds, and Prediction

Will the Arizona Cardinals heap more misery on Head Coach Mike Zimmer and the Minnesota Vikings in Week 2 of the NFL season? Get set up for Vikings @ Cardinals with this betting preview and prediction.
Nikki Adams
Wed, September 15, 10:43 AM EDT

Arizona Cardinals vs. Minnesota Vikings Week 2 Betting Preview, Odds, and Prediction

Date: Sunday, September 19, 2021

Game Time: 4:05 PM ET

Location: State Farm, Glendale, Arizona

TV Network: FOX

Arizona Cardinals Record: (1-0-0 SU, 1-0-0 ATS)

Minnesota Vikings Record: (0-1-0 SU, 0-1-0 ATS)

The Arizona Cardinals threw down the gauntlet in Week 1 and demolished the highly-fancied Tennessee Titans 38-16 at Nissan Stadium. The Minnesota Vikings, in the meanwhile, suffered an overtime loss to the Cincinnati Bengals at Paul Brown Stadium.

Opening Week 2 NFL lines tipped this game with Arizona. The Cardinals were tipped at -2.5 against the spread while the total was projected to 49.5 points before Week 1. After the first week concluded, the Cardinals jumped out to -4, and the total moved up to 51 points with several shops, underscoring just how good Arizona looked in its season opener. Some shops are already showing Cardinals as high as -4.5 but with reduced juice of -105, indicating the NFL line could drop back down to -4 (or lower) later in the week.

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Arizona Cardinals Betting Odds & Overview

The Cardinals were expected to be good, but few realized just how good they could be. Kyler Murray had a monster game as he shredded the Titans for 289 passing yards on 21-of-32 passing attempts and four touchdowns. Although Murray did have one interception in the game, he went on to add a fifth touchdown to his tally when he rushed for a score. 

DeAndre Hopkins connected with Murray on two of those touchdowns in the game. In his second year, the wide receiver is growing into the Cardinals offense nicely, and he put up 83 yards on six receptions. Christian Kirk added another two receiving touchdowns after going 70 yards on five receptions. Rondale Moore, Chase Edwards, and A.J. Green combined for an additional 136 yards, signaling the depth and breadth of the Cardinals receiving corps. 

Chase Edmonds had a standout game rushing for 63 yards on 12 carries, while James Conner added another 53 yards on the ground. However, the defense, led by Chandler Jones' five sacks on Tannehill, really set the tone of the game. 

Minnesota Vikings Betting Odds & Overview

For a second straight season, Mike Zimmer's Vikings kick off their campaign with a loss. The Vikings went into Sunday's clash with the Cincinnati Bengals as the 3-point road chalk but took the "L" after the Bengals' last gasp field goal clinched the 27-23 victory in overtime.

Last season, the Vikings succumbed to a 43-34 loss at home to their division rivals, Green Bay Packers. There's a distinct gap in the quality and talent between the Packers and the Bengals, although it might not be so obvious after last Sunday's round of NFL saw the Packers' shocked by the Saints. Nevertheless, losing to the Bengals, who finished behind a 2-14 record in 2020, isn't the kind of start Zimmer envisioned. 

Cousins went 36-of-49 for 351 passing yards and two touchdowns with no interceptions. Dalvin Cook led the team in rushing with 61 yards and a touchdown, but he also had a fumble lost – controversial though the call was. Adam Thielen, Cousin's favorite target, had a solid day with 76 yards receiving on seven receptions and two touchdowns. 

Arizona Cardinals vs. Minnesota Vikings Odds

Team Moneyline Spread Total
Vikings +175 +4 Over 51 (-109
Cardinals -189 -4 Under 51 (-105)

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Arizona Cardinals vs. Minnesota Vikings Week 2 Betting Preview & Prediction

If there was one knockback on the Cardinals last season, it was their inconsistency. Facing a similar situation, the week following a monster win, Murray and company invariably bottled it. Case-and-point, after an epic win over the Buffalo Bills in Week 10, with Murray throwing a Hail Mary pass to DeAndre Hopkins to clinch the 32-20 win at State Farm, the Cardinals went on a three-game losing streak and finished the season with just two wins in their last seven games. 

It's unlikely Murray will replicate his five-touchdown performance in this game, but it's also unlikely the Cardinals will falter as severely as they did down the stretch in 2020. The Vikings are beatable, and the Cardinals have the offense and defense to overpower the Vikings. This isn't the same team that went to the playoffs two seasons ago and beat the Saints at the Superdome. The chinks in Minnesota's armor were revealed by the departure in talent last season. And it's possible it might rear its ugly head again at the start of 2021, to the detriment of Zimmer, who is very much on the coaching hot seat.

NFL Picks: Cardinals -4 (-110)

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