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Packers vs. Cardinals NFL Week 8 TNF Picks, Betting Odds, and Preview

Packers vs. Cardinals Week 8 Thursday Night Football picks, betting odds, and preview. Who comes out on top when two of the NFL's best teams face off?
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Packers vs. Cardinals NFL Week 8 TNF Betting Odds, Picks, and Preview

Week 8 of the NFL season kicks off with a marquee Thursday Night Football matchup. The Green Bay Packers and Arizona Cardinals have just one loss between them entering their head-to-head clash. Unfortunately, the availability of a certain star is in jeopardy ahead of this highly-anticipated game. As a result, the NFL betting odds have lengthened in favor of the home team.

Packers vs. Cardinals Week 8 NFL Betting Odds, Picks, and Preview

Green Bay Packers (6-1 SU, 6-1 ATS) vs. Arizona Cardinals (7-0 SU, 6-1 ATS)

Date: Thursday, October 28, 2021

Start Time: 8:20 PM EST

Location: State Farm Stadium — Glendale, AZ

TV Coverage: FOX, NFL Network

Packers vs. Cardinals odds

Green Bay Packers Preview

Despite being outgained by over 100 yards last week, the Packers still managed to come away with a win over the Washington Football Team. The 14-point victory was Green Bay’s sixth straight as they continue to lead the NFC North Division following a blowout loss to start the year. Reigning NFL MVP Aaron Rodgers was brilliant as usual in Week 7. He finished with over 270 yards passing and three touchdowns. Davante Adams extended his fantastic start to the year with a team-high in receptions and receiving yards. Unfortunately, his status for Thursday night’s NFL betting matchup is now in doubt.

On Monday, the Packers announced that Adams had tested positive for the infamous virus. With this game taking place on Thursday, he has very little time to test negative twice and thus be cleared to play. Assuming Adams will not be available, Rodgers will have to rely more heavily on Allen Lazard and Randall Cobb in the passing game. Tight end Robert Tonyan had a solid game last week and could also play an increased receiving role. Running back Aaron Jones also has sound pass-catching abilities.

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Arizona Cardinals Preview

Whether Davante Adams plays or not, this TNF NFL betting showdown sets up as a major statement game opportunity for the Cardinals. Arizona improved to 7-0 this past Sunday with a blowout win over the lowly Houston Texans. The Cardinals have been carrying the torch as the NFL’s lone remaining unbeaten team for a few weeks now. Thursday’s game is also highly intriguing from a betting standpoint given that both teams come in with 6-1 records against the spread.

After falling behind 5-0 early, the Cardinals piled up 31 unanswered points en route to the convincing win last week. It marked their sixth victory by double-digits on the year. NFL MVP candidate Kyler Murray turned in another solid performance. He accompanied his 261 yards passing with a trio of scores. One of those went to newly acquired tight end, Zach Ertz, who also led the team with 66 yards receiving. Running backs Chase Edmonds and James Conner combined to rush for over 140 yards and a score. Defensively, Arizona has greatly exceeded expectations. They enter Week 8 ranked second in adjusted efficiency and third in turnover margin (+8).

Packers vs. Cardinals Betting Odds and Line Movement

The following table displays the best Packers vs Cardinals NFL betting odds and lines available in the market.

TeamMoneylineML Implied Win ProbabilitySpreadTotal
Packers+22031.3%+6 (-104)O 51 (-110)
Cardinals-25071.4%-6 (-107)U 51 (-106)

Packers vs. Cardinals odds

After the shocking news regarding Davante Adams and him potentially missing Thursday’s contest, the NFL betting odds nearly doubled in favor of the host Cardinals. Arizona is now laying a full six points across the market after opening at -3.5. The total also predictability dropped just a hair from 52.5 down to 51. This certainly makes sense if Aaron Rodgers is going to be playing without his top target.

Whether it is the Adams news, the Cardinals’ unbeaten record, or a combination of the two, Arizona has attracted the majority of tickets ahead of this TNF matchup. 57% of bets are on the Cardinals at the time of writing. This is a bit surprising considering that the Packers are a very publicly supported team.

Packers vs. Cardinals Betting Picks and Prediction

Perhaps the most under-the-radar unit in all the NFL coming into the year was the Cardinals’ defense. The offseason signing of J.J. Watt added a star pass-rusher on the front line opposite Chandler Jones. Add in young linebackers Zaven Collins and Isaiah Simmons as well as DBs, Byron Murphy and Budda Baker, and Arizona’s defense is truly complete at all three levels. They enter Thursday’s contest tied for the fewest points allowed per game (16.3).

The question then becomes whether or not Aaron Rodgers can solve this unit well enough to keep pace with Kyler Murray on the scoreboard. The Cardinals’ plethora of weapons should have no trouble exposing a shorthanded Green Bay secondary. Without Davante Adams, it’s difficult to envision the Packers returning the favor.

The Packers’ defense was very fortunate to only allow 10 points last week. Whether or not they can play a similar bend-but-don’t-break style successfully on Thursday remains to be seen. The total of 51 does feel a bit high especially if Adams is ruled out. We’ll follow the line move and go under as our best betting lean.

Packers vs. Cardinals NFL Betting Picks: Under 51 (-106)


Henry has had a passion for sports that few can match for as long as he can remember. What started out as a five-year-old taking interest in the New York Jets and their green jerseys has since become a full-fledged career as a writer and sports betting analyst. His coverage primarily includes the NFL, MLB, NBA, NASCAR, college football, and college basketball. In 2020, he ranked among the top-10 most accurate experts ATS in the BettingPros NFL season contest. You can follow Henry’s sports work on Twitter and other social media platforms @HankTimeSports.


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