49ers vs. Bills Prediction, Pick Against the Spread, Latest Odds for Sunday Night Football

The Buffalo Bills will host the San Francisco 49ers on Sunday Night Football.

Poor weather is expected for this highly anticipated matchup.

San Francisco pulls into this contest with a record of 5-6.

The 49ers have been one of the most disappointing teams in the NFL this season.

Entering 2024, San Francisco was the betting favorite to win the NFC.

Now, the 49ers are scrambling just to reach the postseason.

The good news for San Francisco is the NFC West is wide open.

With a win tonight, San Francisco could tie for first place in the division.

However, a loss could really set this team back as we kick off December.

Injuries have played a major role in the 49ers' struggles, but they come into this contest fairly healthy.

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49ers vs. Bills Odds

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49ers vs. Bills Date, Time and Where To Watch

• Date: December 1, 2024
• Time: 8:20 pm ET
• Where To Watch: NBC

49ers vs. Bills Prediction

Brock Purdy returns tonight. Purdy has thrown for 2,613 yards, 13 touchdowns, and eight interceptions.

Christian McCaffrey will look to get going. CMC has rushed for 149 yards in three games, but hasn't scored a touchdown yet. George Kittle leads the 49ers with 642 receiving yards and eight touchdowns.

Buffalo begins this game with a record of 9-2. The season has gone extremely well for this Bills team. Buffalo has an opportunity to get the number one seed in the AFC.

Only the Kansas City Chiefs have a better conference record than the Bills. Buffalo won the crucial head-to-head matchup between the Chiefs earlier in the season. The Bills know they will be tested by a hungry 49ers team tonight.

Sean McDermott's team has won six consecutive games. Buffalo holds a commanding 4.5-game lead in the AFC East. MVP favorite Josh Allen leads the team with 2,543 passing yards, 18 touchdowns, and five interceptions.

James Cook leads the ground game with 596 yards and ten touchdowns. Former Boise State wideout Khalil Shakir has racked up 599 yards and two touchdowns.

49ers vs. Bills Pick

• Pick: San Francisco 49ers +7 -125 Click here for complete 49ers vs. Bills odds

We are getting too many points with the 49ers tonight.

I understand this team has struggled, but they remain one of the top teams in the NFC.

Purdy will be back under center tonight, which will be a huge boost to this offense.

We will see a close back-and-forth contest and a 49ers cover tonight.

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