49ers vs. Bills Same Game Parlay: Can James Cook, Christian McCaffrey Shine in Snow on Sunday Night Football?

We will cook up a same-game parlay for tonight's 49ers vs Bills matchup.

Before we get into this SGP, let's quickly look at this matchup on Sunday Night Football.

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49ers vs. Bills Odds

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49ers vs. Bills Date, Time and Where To Watch

• Date: December 1, 2024
• Time: 8:20 pm ET
• Where To Watch: NBC

49ers vs. Bills Prediction

San Francisco comes into this game with a record of 5-6. The 49ers began the year as one of the betting favorites to win the Super Bowl.

After reaching the Super Bowl last season, San Francisco has been extremely disappointing this season. Injuries have played a key role in the struggles for the 49ers.

Christian McCaffrey began the season on the IR as the reigning offensive player of the year. CMC has played in the last three games, and has yet to find the end zone this season.

Last weekend, starting quarterback Brock Purdy was out with an injury. Purdy will return tonight.

Buffalo represents a 9-2 record. Regular season success has not been an issue for Buffalo. The Bills' struggles have come in the postseason. Despite being a consistent playoff team, Buffalo has reached just one conference championship in the Allen era in the last few years.

Josh Allen is the current betting favorite to win MVP. Buffalo has won six consecutive games. The Bills point differential of +106 is the best in the AFC.

49ers vs. Bills Same-Game Parlay

Leg 1: Christian McCaffrey Anytime TD Scorer

I anticipate a heavy workload tonight for the 49ers running back.

CMC will be playing in his fourth game of the season.

McCaffrey will be at full strength tonight and is due to find the end zone.

Leg 2: James Cook Anytime TD Scorer

Cook has quietly been one of the best running backs in football this season.

The former Georgia standout has rushed for 10 touchdowns this season, ranking fourth in the NFL.

Leg 3: Brock Purdy 225+ Pass Yards

The game script will favor this prop.

I anticipate a close back-and-forth game.

The game script will force Purdy to throw the football early and often.

49ers vs. Bills Same-Game Parlay (+430) (Bet $100 to Collect $530)

• Leg 1: Christian McCaffrey Anytime TD Scorer
• Leg 2: James Cook Anytime TD Scorer
• Leg 3: Brock Purdy 225+ Pass Yards

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