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Barcelona vs. Inter Milan Prediction, Best Bet, Latest Champions League Semifinal Odds for Leg 2

After a high-flying first leg of this Champions League Semifinal battle last week, Barcelona and Inter Milan will meet again on Tuesday evening in San Siro. While Inter is home this time, Barcelona now has Robert Lewandowski back in the lineup, and they will continue to display the explosive offense that found them three goals. Matt MacKay previews his Barcelona vs. Inter Milan Champions League showdown, and gives his best bet for Leg 2.

Robert Lewandowski Barcelona

Matt MacKay

| 5 min

Barcelona vs. Inter Milan Prediction, Best Bet, Latest Champions League Semifinal Odds for Leg 2

Inter Milan returns home to Stadio Giuseppe Meazza in Milano, Italy to host the second leg of the Champions League Semifinal match against Barcelona on Tuesday. Both clubs put on a goal-scoring clinic during the first leg last week, winding up tied 3-3 on aggregate heading into tonight's high-stakes game.

Barcelona gets back one of its primary goal scorers, F Robert Lewandowski. The 36-year-old striker has 11 goals in Champions League play, despite not playing since suffering an injury in Spanish LALIGA on April 19th. Meanwhile, Lautaro Martínez, Inter's leading goal scorer (8), has overcome his thigh injury and will be on the pitch against Barcelona.

Matt MacKay has his latest pick for the second leg of this UEFA Champions League Semi-Finals match between Inter Milan and Barcelona. Follow Matt's X account for more betting analysis and free picks.

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Barcelona vs. Inter Milan Odds

  • Home: Inter Milan (+170)
  • Draw: (+275)
  • Away: Barcelona (+150)

Barcelona vs. Inter Milan Date, Time, And Where to Watch

  • Date: Tuesday, May 6, 2025
  • Time: 3:00 PM ET
  • How to Watch: CBS, Paramount+

Click here for complete Barcelona vs. Inter Milan Odds

Barcelona vs. Inter Milan Prediction

Inter grabbed an early 2-0 lead on the road in Spain during Leg 1. This included a goal in the first minute to seize momentum. Barcelona countered with its first goal three minutes after going down 2-0, cutting the deficit to one. Barcelona F Ferran Torres leveled the score 2-2 going into half time.

Inter's Denzel Dumfries scored his second goal of the match in the 63rd minute to briefly take the lead for the third time in Leg 1. An own goal happened two minutes later as Barcelona benefitted from this lucky break, finishing the match tied 3-3.

The return of Barcelona F Robert Lewandowski is massive. The Spanish LALIGA club is undoubtedly the most talented offense remaining in the UEFA Champions League, especially with Lewandowski back in the fold. It remains to be seen how much time the Polish forward will log but expect an impactful performance when Lewandowski is in the attacking third.

Inter isn't going to be a pushover, especially at home, with multiple ways to effectively counter Barcelona's high press attack. However, I can't ignore the value we're getting on the Spaniards to advance to the Champions League Final.

The current To Qualify betting market is essentially a pick 'em. Barcelona available to bet at -112 odds, compared to -106 odds for Inter. Barcelona isn't a great defensive team but their offense is high-octane and dangerous from anywhere on the pitch.

If Barcelona grabs an early lead, it's going to be more difficult for Inter to catch up. The Italian A Serie A club has talent on offense but it's a roster built for stout defense and counter-attacks.

We saw Barcelona erase a deficit multiple times in Leg 1 without Lewandowksi. His return should spark confidence throughout the lineup, as he and Raphina have netted a combined 23 goals during the Champions League tournament.

I'm backing the better offense in Barcelona. The Champions League Final is at stake in this elimination game and Lewandowski's availability is the primary factor in this handicap. By picking Barcelona to qualify for the next round, we don't need to sweat the 90 minute result if this match requires penalties.

Inter won't go quietly, but they are outmatched against Barcelona's scoring depth and firepower. Let's bet a unit on Barcelona to qualify for the next round at -112 odds.

Barcelona vs. Inter Milan Pick

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