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Arizona Cardinals vs. Kansas City Chiefs Betting Preview, Odds and Overview

Two of the league's talented young quarterbacks will face off against each other in Phoenix during Sunday afternoon's late slate. The Chiefs will sport a new look without Tyreek Hill as they travel to the desert to take on Kyler Murray and the Cardinals.
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Arizona Cardinals vs. Kansas City Chiefs Betting Preview, Odds, and Overview

Kyler Murray and Patrick Mahomes have both secured massive second contracts with their respective franchises. The Chiefs and Cardinals will look to validate the return on investment during a Week 1 tilt in Arizona.

Arizona is an underdog at home against a Chiefs offense that is no longer rostering wide receiver Tyreek Hill. Head coach Andy Reid is known for his exotic playcalling and hybrid schemes on offense, which could take off with an entirely upgraded receiving corps and a deeper backfield.

Can the Cardinals take the next step as a serious playoff contender? Yes, they managed to earn an NFC Wild Card berth against the Los Angeles Rams in 2021. Yet the consistent mid-season plateau Murray has displayed in each of his previous two years is concerning. Will the addition of former college teammate and Baltimore Ravens wideout, Marquise "Hollywood" Brown, be enough to make Arizona an offensive juggernaut?

The Chiefs are road favorites despite losing Hill and safety Tyrann Mathieu to free agency. A slew of rookies and free agents will surround Mahomes as he attempts to get the Chiefs off to a 1-0 start.

Arizona Cardinals vs. Kansas City Chiefs Start Time, Where to Watch, and Odds

  • Date: Sunday, September 11
  • Time: 4:25 pm ET
  • Where to Watch: CBS
  • Location: State Farm Stadium (Glendale, AZ)
  • Arizona Cardinals Record: 0-0
  • Kansas City Chiefs Record: 0-0

Click Here for Cardinals vs Chiefs Odds

Arizona Cardinals vs. Kansas City Chiefs Preview

Arizona and Kansas City have not played each other since 2018, resulting in a 26-14 win during Mahomes' miraculous 50 passing touchdown season. While he was impressive, completing 21 passes for 249 yards and two touchdowns, he was not facing Kyler Murray.

The Cardinals' fourth-year quarterback was scrutinized heavily this offseason during his contract renewal. It ultimately turned into a massive payday for Murray but he will be without veteran wideout DeAndre Hopkins against a tough defense led by Chiefs DC, Steve Spagnuolo. Chase Edmonds was another loss in free agency, so Arizona is forced to rely on James Conner to attempt replicating his 18-touchdown performance.

Both defenses managed to rank inside the top ten for total points allowed last season, which could result in a lower-scoring matchup than anticipated. Murray completed 2021 with one of the best deep ball (20+ yards) completion percentages and he ranked first in money throws, which factors in clutch completions amongst other statistics. The Cardinals have a formidable duo at linebacker with Isaiah Simmons and Zaven Collins, while keeping Pro-Bowl safety Budda Baker lurking on the back end of the defense.

Kansas City's playcalling is superior when assessing the resumés of Kliff Kingsbury and Andy Reid. The Cardinals deploy an air-raid, RPO-styled scheme, while the Chiefs could see increased pre-snap motions and intermediate passing with JuJu Smith-Schuster, Marquez Valdes-Scantling, and Ronald Jones offering their skillset. Kingsbury has yet to win a playoff game, while Reid is a decorated veteran of the postseason with a 2019 Super Bowl championship win over the San Francisco 49ers.

Arizona Cardinals vs. Kansas City Chiefs Odds

The latest Arizona Cardinals vs. Kansas City Chiefs odds heavily favor the Kansas City Chiefs on the moneyline and the point spread.

Last season, Arizona went 10-8 against the spread during their NFC Wild Card appearance. In their 17 regular season games, the Cardinals posted a 10-7 record ATS, tied fifth-best amongst all 32 teams.

Kansas City was slightly less profitable against the spread, going 10-10 before an exit against the Cincinnati Bengals during the AFC Championship game. The Chiefs were 8-9 in 17 regular season games ATS, which ranked ninth in the league amongst seven other teams.

TeamML OddsOver/UnderPoint Spread
Cardinals+200Under 54 (-110)+6 (110)
Chiefs-240Over 54 (-110)-6 (-110)

Arizona Cardinals vs. Kansas City Chiefs Betting

Sportsbooks are expecting Patrick Mahomes to win without much difficulty in Glendale. How does the betting public feel about this quarterback battle?

Nearly three in four public bettors are backing the Chiefs to earn a win on the road against the Cardinals. 73 percent of all moneyline bets on this game are backing the Chiefs, while just 27 percent are backing the Cardinals.

TeamPublic Betting %

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Matt is an avid writer, editor, and researcher. He enjoys analyzing the game within the game which is fantasy sports and sports betting. Music is another constant in his daily life. Matt loves spending time with his wife and three pets. He likes to read, listen to podcasts, and is constantly motivated to create the most accurate and engaging content in the sports betting industry.


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