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Best College Basketball Bets Today: Predictions, Picks, and Odds for Wednesday, January 22

The college basketball slate is loaded up again on Wednesday night for some mid-week action. Matt McCuen has compiled his best bets and picks against the spread for January 22nd, and lays out his predictions below. Read on for Xavier vs. St. John's betting picks and others.

Matt McCuen - January 22, 2025, 2:53 PM EST

4 min

Best College Basketball Bets Today: Predictions, Picks, and Odds for Wednesday, January 22

With conference play in full swing, Wednesday's are one of the heaviest days for mid-week CBB action.

We will dive into my two favorite bets for tonight's college basketball slate.

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Best College Basketball Bets Today - January 22nd

Xavier vs. St. John's Odds

Xavier Musketeers vs. St. John's Red Storm Prediction

The Musketeers come into this game with a record of 12-7. That record has the Musketeers placed in sixth in the Big East, and they've won three straight games to get there.

On Saturday, the Musketeers pulled off a shocking upset over the 7th-ranked Marquette Golden Eagles on the road. Senior Zach Freemantle leads the team with 16.8 points and 7.8 rebounds per game.

St. John's supports a record of 16-3. Rick Pitino's team begins the game ranked 20th in the nation. The Red Storm have not reached the big dance since 2019, and are on the fast track to changing that.

St. John's has won five straight games. The last loss for the Red Storm came on December 31st against the Creighton Bluejays, 57-56. Miami native RJ Luis Jr. leads the team with 17.8 points per game and 6.5 rebounds.

Xavier vs. St. John's Best Bet

The line tonight screams St. John's.

Xavier is coming to a big-time road win over Marquette, but they are in a letdown spot tonight.

The Red Storm will control the pace of this game, and have too much offensive firepower for Xavier to match.

Click here for the latest College Basketball odds

Miami Florida vs. Stanford Odds

Miami Florida vs. Stanford Prediction

Miami starts the game with a record of 4-14. The season has been a disaster for Miami. Entering the season, the Canes were expected to be an above-average team. Miami opened the season 3-0, but have lost 14 of their last 15 games. The last win for Miami came on December 15th against Presbyterian.

Former head coach Jim Larranaga stepped down early in the season, throwing the team into further chaos. Matthew Cleveland leads the Canes with 13.8 points per game.

Stanford begins the game with a 12-6 record. That record places them 7th in the ACC. Stanford has exceeded expectations early in the season, and is coming off a notable win over North Carolina.

The Cardinal have won three of their last four games. Senior Maxime Raynaud leads the team with 20.8 points per game and 11.6 rebounds.

Miami Florida vs. Stanford Pick

Miami will continue its struggles tonight. The Canes have been awful on the road this year, with a 0-3 record.

Meanwhile, Stanford has played their best basketball at home this season (9-3).

Let's cash both of these winners tonight!

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