NFL Week 6 Picks: Best Betting Picks for Sunday's NFL Action

NFL Week 6 Picks: Best Betting Picks for Sunday's NFL Action

Our expert handicappers touch down with the best free picks for Week 6 of the NFL regular season.  

We made it to Week 6 after an exciting start to the season. The slate begins on Thursday night with the Seattle Seahawks taking on the San Francisco 49ers in an NFC West clash, and finishes with a Bills vs. Jets headliner on Monday Night Football.

Make sure you check out the best picks from across the league from our stable of expert handicappers by clicking the links below.

Matt McCuen

• The San Francisco 49ers will look to get back on track when they battle the Seattle Seahawks on the road tonight. Can Brock Purdy lead the Niners to a divisional victory on Thursday Night Football? Matt McCuen analyzes this NFC West matchup and provides his prediction and pick for 49ers vs. Seahawks. - Click here to read more
• Pick: San Francisco 49ers -3 -120 Click here to see which sportsbook has the best odds
• The Seattle Seahawks will host the San Francisco 49ers as both squads look to stop their recent losses. Can DK Metcalf and Deebo Samuel get off to the races early? Matt McCuen is targeting both stars with his top player props in the first touchdown market for 49ers vs. Seahawks on TNF. - Click here to read more
• Pick: DK Metcalf +800 Click here to see which sportsbook has the best odds
• Pick: Deebo Samuel +850 Click here to see which sportsbook has the best odds
• The Seattle Seahawks will battle the San Francisco 49ers on Thursday Night Football tonight. Can DK Metcalf and Jaxon Smith-Njigba keep the Seahawks in this rivalry showdown? Matt McCuen brings us his same-game parlay for 49ers vs. Seahawks on TNF. - Click here to read more
• San Francisco 49ers vs. Seattle Seahawks Same Game Parlay (+642)
• The Baltimore Ravens will take on the Washington Commanders on Sunday afternoon in a DMV rivalry renewed. Can Lamar Jackson and the Ravens silence the red-hot Commanders? Matt McCuen provides his prediction and pick for Commanders vs. Ravens. - Click here to read more
• Pick: Baltimore Ravens -6.5 -110 Click here to see which sportsbook has the best odds
• The New Orleans Saints will host the Tampa Bay Buccaneers with a backup quarterback. Can Spencer Rattler stun the Bucs in his NFL debut? Matt McCuen is targeting the underdog with his Bucs vs. Saints prediction and pick. - Click here to read more
• Pick: New Orleans Saints +3.5 -110 Click here to see which sportsbook has the best odds
• The Detroit Lions will look to snap a six-game losing streak in their series against the Dallas Cowboys on Sunday afternoon. Can Dak Prescott and the Cowboys upset the Lions and continue their dominance against Detroit? Matt McCuen analyzes his matchup with his prediction and pick for Lions vs. Cowboys. - Click here to read more
• Pick: Dallas Cowboys +3.5 -115 Click here to see which sportsbook has the best odds

MJC Locks

• The San Francisco 49ers will look to run up the score against the Seattle Seahawks on Thursday Night Football. Can Deebo Samuel and Brandon Aiyuk get in the end zone on TNF? MJC Locks brings us his top touchdown scorer bets for 49ers vs. Seahawks. - Click here to read more
• Pick: Deebo Samuel Anytime TD +130 Click here to see which sportsbook has the best odds
• Week 6 in the NFL starts early in London again to coast through a full day of action. MJC Locks is getting you ready with his best anytime TD scorer bets for Week 6 Sunday, including A.J. Brown returning for the Eagles. Get in on these best prop bets for October 13th. - Click here to read more
• Pick: Josh Jacobs Anytime Touchdown Scorer (-150) Click here to see which sportsbook has the best odds for this pick

Calling Our Shot

• Calling Our Shot delivers their favorite FanDuel Same Game Parlay for Thursday Night Football between the 49ers and Seahawks on October 10th! This parlay is a winner! - Click here to read more

Oddschecker compares the very latest NFL odds from the best sportsbooks across the USA.