Oddschecker+
Positive EV Bets
Odds format
United States
Canada
OH
United States
Canada
Trevor Lawrence Jaguars throw

Jacksonville Jaguars vs. Buffalo Bills Prediction, Pick Against the Spread, Latest Odds for MNF

The Jacksonville Jaguars will look to avoid an 0-3 start on Monday Night Football against the undefeated Buffalo Bills. Can Trevor Lawrence and the Jags bounce back in Week 3 on MNF? Matt McCuen provides his prediction and pick for Jaguars vs. Bills.

Matt McCuen - September 23, 2024, 12:53 PM EDT

5 min

Jacksonville Jaguars vs. Buffalo Bills Prediction, Pick Against the Spread, Latest Odds for MNF

The Jacksonville Jaguars and the Buffalo Bills will get together for a prime-time affair Monday Night Football.

The Jags enter this game in desperation mode after starting the season 0-2. In Week 1, Jacksonville let a game slip away as they led most of the way against the Miami Dolphins. The Jaguars were defeated on a last-second field goal by Dolphins kicker Jason Sanders.

In Week 2, the Cleveland Browns defeated the Jags with a final score of 18-13. Jacksonville never led in the loss.

Jacksonville Jaguars vs. Buffalo Bills Date, Time and Where to Watch

  • Date: September 23, 2024
  • Time: 7:30 pm ET
  • Where to Watch: ESPN

Jacksonville Jaguars vs. Buffalo Bills Odds

  • Spread: Jaguars +5.5 (-115), Bills -5.5 (-105)
  • Total Odds: O 46.5 (-110), U 46.5 (-110)
  • Moneyline Odds: Jaguars (+210), Bills (-250)

Jacksonville Jaguars vs. Buffalo Bills Prediction

Former Clemson standout Trevor Lawrence leads the Jaguars offense. Lawrence has thrown for 382 yards and one touchdown.

25-year-old Travis Etienne Jr. leads the backfield. Etienne has rushed for 96 yards and a pair of touchdowns.

Rookie Brian Thomas Jr. leads the team with 141 yards and one touchdown.

The Jacksonville defense ranks 9th in the NFL, allowing the opposition 19.0 points per game.

Buffalo will look to stay perfect in the young season. The Bills survived a scare in Week 1 against the Arizona Cardinals. Going into the locker room, Buffalo trailed the Cardinals 17-10. Buffalo trailed by as many as 14 points in the comeback win.

In Week 2, it was all Bills as they went into Miami and took the Dolphins down 31-10.

Veteran signal caller Josh Allen has thrown for 371 yards and three touchdowns. Perhaps the most impressive stat for Allen is zero interceptions after two weeks.

James Cook leads the Bills ground game. Cook has rushed for 149 yards and two touchdowns.

Khalil Shakir has been the top option in the passing game with 96 yards and one touchdown.

Buffalo ranks 9th in points allowed per game (9.0).

Jacksonville Jaguars vs. Buffalo Bills Pick

We will take the points with the underdog tonight.

Buffalo comes into this contest banged up on the defensive side of the ball.

Jacksonville can move the football and keep pace in this game.

I expect a desperate and strong effort from the Jags tonight.

Pick: Jacksonville Jaguars +6 -120 Click here to see which sportsbook has the best odds

NFL Odds

onboarding-background

Join the oddschecker Community

Bet with Intelligence

Sign-up for an oddschecker account to get expert picks, ai-driven betting tools and best odds across sportsbooks.