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Kyler Murray Cardinals

Chargers vs. Cardinals Prediction, Betting Pick, Latest Odds for Monday Night Football

The Arizona Cardinals will look to shake off last week's road loss when they host the Los Angeles Chargers on Monday Night Football. Can Kyler Murray and the Cardinals bounce back and upset Jim Harbaugh's Chargers tonight? Matt McCuen provides his best betting pick for Chargers vs. Cardinals on MNF.

Matt McCuen - October 21, 2024, 1:47 PM EDT

4 min

Chargers vs. Cardinals Prediction, Betting Pick, Latest Odds for Monday Night Football

The Arizona Cardinals will host the Los Angeles Chargers on Monday Night. State Farm Stadium will be the site for this highly-anticipated matchup.

Arizona begins this contest with a record of 2-4 on the young season. Tonight is a crucial game for the Cardinals to keep their playoff hopes alive. With a loss tonight, the Cardinals will dig themselves quite a hole to get out of. The Cardinals have pushed back-to-back four-win seasons after going 11-6 in 2021.

Since 2016, Arizona has reached the playoffs just once. Arizona picked up a thrilling win in Week 5 on the road against the San Francisco 49ers. Last weekend, the Cardinals got blown out 34-13 on the road against the Green Bay Packers.

Los Angeles Chargers vs. Arizona Cardinals Odds

  • Spread: Chargers -1.5 (-110), Cardinals +1.5 (-110)
  • Total Odds: O 44.5 (-110), U 44.5 (-110)
  • Moneyline Odds: Chargers (-120), Cardinals (+100)

Los Angeles Chargers vs. Arizona Cardinals Date, Time, and Where To Watch

  • Date: October 21, 2024
  • Time: 9:00 pm ET
  • Where To Watch: ESPN+

Los Angeles Chargers vs. Arizona Cardinals Prediction

Kyler Murray leads the Arizona offense. Murray has thrown for 1,186 yards, eight touchdowns, and two interceptions.

Veteran James Conner has scampered for a team-best 403 yards and three touchdowns.

Rookie Marvin Harrison Jr. leads the team with 279 receiving yards and four touchdowns.

Arizona ranks 29th in points allowed per game (27.2).

Los Angeles rolls into this contest with a 3-2 record. The Jim Harbaugh era is off to a strong start in LA. The Chargers were one of the most disappointing teams in football last year (5-12). The disappointing season called for the firing of former head coach Brandon Staley.

Since 2019, the Chargers have reached the playoffs just once. The strength of this Chargers team has been its league leading defense, allowing opponents just 13.2 points per game.

Justin Herbert leads the Chargers offense, throwing for 815 yards, six touchdowns, and one interception.

Former Ohio State standout Jk Dobbins has rushed for a team-high 438 yards and three touchdowns.

Rookie Ladd McConkey has been the top target in the passing game, racking up 219 yards.

Los Angeles Chargers vs. Arizona Cardinals Pick

We will ride with the home underdog tonight.

While the Chargers have produced a solid record to start the season, their three wins are against some of the worst teams in football (Raiders, Panthers, and Broncos).

The Cardinals' offense will have success tonight, moving the football and controlling the pace of this game.

Let’s stay hot and cash tonight!

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