Cardinals vs. Seahawks Prediction, Betting Pick, Latest NFL Odds for Week 10
The Seattle Seahawks will look to continue their winning streak, this time hosting the new-look Arizona Cardinals. Can Jacoby Brissett and the Cards get revenge on the Seahawks in this NFC West clash? Let's take a look at this Cardinals vs. Seahawks prediction for Week 10.
OC Staff - November 9, 2025, 2:15 PM EST
5 Minute ReadCardinals vs. Seahawks Prediction: Can Jacoby Brissett, Cardinals Stun Red-Hot Seahawks in NFC West Battle?
As the NFL season hurtles towards its crucial middle stretch, a compelling West Coast clash unfolds this weekend. The surging Seattle Seahawks, boasting a 6-2 record and riding a three-game winning streak to secure the #3 spot in the conference, welcome the Arizona Cardinals (3-5, #12 in conference, Won 1).
While the Seahawks look to cement their playoff aspirations with a 2-2 home record, the Cardinals, also 2-2 on the road, are desperate to climb out of the basement and inject some hope into their season. This encounter promises to be a battle of contrasting trajectories, decided by a handful of critical individual matchups.
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Cardinals vs. Seahawks Date, Time, and Where to Watch
- Date: Sunday, November 9, 2025
- Time: 4:05 PM ET
- How to Watch: CBS
Cardinals vs. Seahawks Odds
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Cardinals vs. Seahawks Prediction
The spotlight undoubtedly falls on Seahawks quarterback Sam Darnold, who steps into the starting role with an intriguing set of data points. While his overall projection for this game (21/30, 267.8 Yds, 0.6 INT) is solid, it's his historical performance against top-tier pass defenses that truly raises eyebrows. In 8 career games against a top-10 pass defense, Darnold has consistently delivered, sporting an impressive 110.0 Passer Rating, averaging 257.2 passing yards per game, and maintaining an excellent 4.5 TD:INT ratio (18 Total Pass TD vs. 4 Total INT). This is not the inconsistent quarterback many remember. He now faces an Arizona Cardinals pass defense ranked 8th in QB Rating Allowed, though their pass rush is a more modest 20th in sacks.
This matchup presents a fascinating dynamic: Can Darnold continue his surprising trend of elevating his play against quality secondaries, or will Arizona's opportunistic defense capitalize on any potential rust or miscommunication? Given Darnold's historical resilience in these spots, coupled with Arizona's less-than-elite pass rush, the pathway for him to succeed appears open. In fact, our model highlights this potential, finding a strong edge with a positive Expected Value (EV) of 8.8% on Over 267.5 Passing Yards at 1.91 (-110). This suggests the market may be underestimating Darnold's ability to navigate a challenging, but not overwhelming, Cardinals pass defense.
On the other side of the ball, the Cardinals' primary offensive weapon, wide receiver Marvin Harrison Jr., faces perhaps his toughest test yet against one of the league's premier pass defenses. Harrison Jr. is projected for a modest 4.6 receptions and 61.1 receiving yards against a Seattle unit ranked 6th in QB Rating Allowed and 3rd in sacks. This is a classic "unstoppable force meets immovable object" scenario. Can the rookie's elite talent and route-running prowess carve out space against a secondary that rarely surrenders big plays?
The Cardinals' ability to move the chains will heavily rely on Harrison Jr.'s capacity to win these individual battles, even if his quarterback, Jacoby Brissett, is under duress. Brissett himself has limited history against top-10 pass defenses (1 game, 89.2 Passer Rating, 2.0 TD:INT ratio), and Seattle's formidable pass rush will only amplify the challenge. Yet, despite the formidable opposition, our models see significant hidden value in Harrison Jr.'s potential. There's a strong edge with an Expected Value (EV) of 5.9% on Over 61.0 Receiving Yards at 1.91 (-110), suggesting that even against a lockdown defense, Harrison Jr.'s talent could lead to a more productive outing than market expectations. This is a testament to his high ceiling and the potential for the Cardinals to force-feed their star receiver.
While Harrison Jr. tries to find space, his quarterback, Jacoby Brissett, faces an immediate and suffocating challenge. Brissett's projection of 20/32 for 216.4 yards and 0.6 INT paints a picture of a cautious, managing performance. However, his one historical outing against a top-10 pass defense (89.2 Passer Rating) offers limited, but not particularly inspiring, context. The real hurdle for Brissett will be Seattle's defense, which is not just elite against the pass (6th in QB Rating Allowed) but also boasts a fearsome pass rush, ranking 3rd in sacks.
This relentless pressure will be critical in disrupting Brissett's timing and forcing hurried throws. Arizona's ability to protect their quarterback and establish any semblance of a running game – especially against Seattle's 2nd-ranked rush defense (Emari Demercado projected for just 33.5 rushing yards, with a slight negative EV on his 'Under' prop at 1.91 (-110)) – will dictate their offensive viability. If Seattle's front seven can consistently collapse the pocket, it will severely limit Harrison Jr.'s opportunities and likely lead to a long day for the Cardinals' offense.
The most decisive factor in this contest will likely be the Seattle Seahawks' defensive dominance, particularly their pass rush, against Jacoby Brissett. If the Seahawks can consistently apply pressure and disrupt the Cardinals' passing game, it will nullify Arizona's ability to keep pace, regardless of Marvin Harrison Jr.'s individual brilliance, paving the way for Sam Darnold and the Seahawks offense to capitalize on their own favorable matchups.
Cardinals vs. Seahawks Pick
- Pick: Cardinals +7 (-110) Check out these best odds at DraftKings Sportsbook
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