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The Clemson Tigers make their first West Coast conference trip for a Friday night ACC matchup against California at Memorial Stadium. Can Tait Reynolds and Clemson's improving rushing attack handle the cross-country setting against Jaron-Keawe Sagapolutele and a Cal defense that has been creating turnovers at one of the highest rates in the country? Check out this Clemson vs. California prediction and best bet for Friday, September 25.

The Northwestern Wildcats take their unbeaten start into Bloomington for a Friday night Big Ten opener against defending national champion No. 5 Indiana. Can Aidan Chiles and Chip Kelly's rebuilt offense carry the momentum from a dominant win over Colorado into its first road test against Josh Hoover and an Indiana defense coming off consecutive shutouts? Check out this Northwestern vs. Indiana prediction and best bet for Friday, September 25.

The Navy Midshipmen return from an open week for a Friday night American Conference road matchup against UAB at Protective Stadium. Can Braxton Woodson and one of the nation's most productive rushing attacks maintain Navy's recent dominance of the series against a Blazers team that has been much tougher at home? Check out this Navy vs. UAB prediction and best bet for Friday, September 25.

The Army Black Knights open a difficult road stretch Friday afternoon against a Temple team coming off one of the most dramatic losses of Week 3. Can Cale Hellums and Army's option attack capitalize on extra preparation time against an Owls team that has shown significant improvement offensively? Check out this Army vs. Temple prediction and best bet for Friday, September 25.

The Atlanta Falcons visit the Green Bay Packers on Thursday Night Football for an NFC matchup at Lambeau Field. Can Michael Penix Jr., Bijan Robinson and Jordan Love capitalize on favorable player prop numbers under the primetime lights? Check out these Falcons vs. Packers 3 best bets for Thursday, September 24.

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