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The Philadelphia Eagles visit the Tennessee Titans in Nashville for a Week 2 matchup between a defending division champion and a Tennessee team trying to recover from an ugly offensive opener. Can Jalen Hurts, Saquon Barkley and Cam Ward determine whether this game ever escapes a defense-first script? Check out this Eagles vs. Titans prediction and best bet for Sunday, September 20.

The New Orleans Saints visit Baltimore after both teams produced explosive Week 1 offenses, but the Ravens enter their home opener with significant injuries across the receiving corps and offensive line. Can Lamar Jackson, Derrick Henry and Tyler Shough generate another offensive outburst with several important playmakers either sidelined or limited? Check out this Saints vs. Ravens prediction and best bet for Sunday, September 20.

The Pittsburgh Steelers travel to Foxborough for the Patriots' home opener in a matchup between Aaron Rodgers and Drake Maye after both offenses played low-scoring games in Week 1. Can Maye overcome the loss of A.J. Brown while Rodgers navigates a New England defense that allowed only 13 points in Seattle? Check out this Steelers vs. Patriots prediction and best bet for Sunday, September 20.

The Cleveland Browns travel to Tampa Bay for a Week 2 matchup featuring Baker Mayfield's first home game against the franchise that drafted him No. 1 overall. Can Mayfield, Emeka Egbuka and Deshaun Watson determine whether Tampa Bay turns its home opener into a convincing rebound performance? Check out this Browns vs. Buccaneers prediction and best bet for Sunday, September 20.

Get our Paderborn vs TSG Hoffenheim prediction, betting picks, odds, and projected lineups for Sunday's Bundesliga game. Find key Same Game Parlay picks.

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Explore confirmed Manchester City vs Sunderland lineups, key betting odds, and our expert game prediction ahead of this exciting Premier League clash.

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