In addition to the 'new big four' we have last year's Flushing Meadows finalists in Kei Nishikori and Marin Cilic. Nishikori is the fourth seed and he has an interesting opener against Benoit Paire with only Grigor Dimitrov after that blocking his path to the semi-finals. Cilic just does not seem to be in the same form as last year.
Federer would be my idea of a winner at this stage as I have doubts over Djokovic after Cincinnati and I struggle to see Murray beating Wawrinka, Federer and Djokovic to take the title, At 9-2, the Swiss veteran still looks value even for an each-way bet.
Nadal looks to be a shadow of his former self and I'll be opposing him at every opportunity. He faces rising star Borna Coric who looks a future top-five player and the Croatian will give Nadal plenty to think about. At a general 4-1, Coric has to be a play.
Backing Fabio Fognini to win any match is risky but I can't resist him against Steve Johnson. The American is from the same sort of mould as an Isner or a Querrey and has taken some notable scalps recently including Jo-Wilfried Tsonga. But 2-1 about Fognini just looks far too big to my eyes.
In the women's, Serena Williams looks nigh on unstoppable in her bid for a calendar Grand Slam. With doubts over Victoria Azarenka's fitness, Simona Halep is the each-way outright bet at 12-1 after pushing Williams in the Cincinnati final. The Romanian struggled for form in Paris and at Wimbledon but she's found her stride in recent weeks on the hard courts Stateside.
Maria Sharapova has not played since Wimbledon and must be opposed first up against Daria Gavrilova. This has been a breakthrough year for the Australian-based Russian and she will make Sharapova hit far more balls than she will want to. Gavrilova beat Sharapova at Miami this season and, though she lost their next meeting on the clay at Rome, 3-1 is a huge price.
Samantha Stosur has not been in the best of form in the States and her last match saw her go out in Cincinnati to Timea Babos. The pair meet again in the opening round in New York and the Hungarian, best known as a doubles player but improving in singles, is worth a bet at the 2-1 available.