NFL Survivor Pool Predictions, Picks, Strategy for Week 6 Eliminator Challenge, Knockout Games
After a boring first month of NFL Survivor, we finally saw some upsets in Week 5. Half of the entries were wiped out on the two most popular teams, and now it's time to get strategic in Week 6. Peter Alexis breaks down the best picks for NFL Survivor Week 6, starting with the Packers.
Peter Alexis - October 9, 2025, 3:55 PM EDT
5 Minute ReadNFL Survivor Predictions, Picks: Should You Trust the Safe Side in Packers or Take a Risk in Week 6?
Welcome back to NFL Survivor Week 6, after we finally got some carnage. In most pools, nearly 55% of entries were eliminated, going down on popular picks like the Cardinals, Rams, and Bills. If you escaped through, you are now holding some solid value on your entry, and it's time to find out where to place it next.
It's a good opportunity to get strategic here in Week 6, especially with a massive 14-point favorite like the Packers on the board. Over 40% of users will probably take the Packers, as most still have them available. Anyone that used them would have used it in Weeks 3 or 4, where they had a shocking loss to the Browns and a tie. Do you want to go with the main flow and get the easy win over the Bengals this week, or will you take an alternate route?
In our main survivor pool, we've used the Broncos, Cardinals, Seahawks, Texans, and now Lions. The idea is to try and save the top teams to trust in later weeks. The main focus is using home teams and fading bad teams on the road, instead of targeting live dogs who can cause a ruckus like the Titans and 49ers last week. As we turn to Week 6, let's evaluate the best choices for NFL Survivor 2025.
Looking for advanced AI predictions and props to enhance your NFL betting? Try out oddschecker+ now on this limited time 7-day free trial!
NFL Survivor Picks
1. Green Bay Packers (vs. Cincinnati Bengals)
- Spread: Lions -14
- Moneyline: -1050
- FairPlay AI Win Probability: 88%
- Mathematical Best Use Remaining: 1st out of 13
- Estimated Usage Percentage: 42% (Highest of Week)
Once again, the opponent of the Cincinnati Bengals is the best selection for NFL Survivor this week. In Week 5, the Lions led by three scores for the majority of the afternoon, before Cincy crept back in with some garbage touchdowns. They still lost by double digits and didn't even cover the +10.5 spread, but finally did show signs of life. That wasn't enough for the front office, as they hired Joe Flacco mid week.
The 41-year-old veteran journeyman will now start for the Bengals after meeting his teammates two days ago, somehow giving them a better chance than Jake Browning? The spread hasn't moved either way, nor should it. Cincy plays almost no defense, and Flacco isn't going to put up 30+ on Micah Parsons and the Packers. If you survived the carnage of last week, the Packers are the safe play here. They come off a tie and a bye, desperate to get back in the win column with a blowout at home. It's the best time to use the Packers, though there are a few spots upcoming if you wanted to save them. But they aren't going to lose this one, and you can feel safe on Green Bay here with an 88% chance of victory (more like 100%).
2. Indianapolis Colts (vs. Arizona Cardinals)
- Spread: Colts -7
- Moneyline: -340
- FairPlay AI Win Probability: 73%
- Mathematical Best Use Remaining: 2nd out of 13
- Estimated Usage Percentage: 5%
Hopefully you skipped using the Arizona Cardinals last week against the Tennessee Titans, as Kyler Murray and the Cardinals collapsed in spectacular fashion in the fourth quarter for one of the most shocking losses of recent memory. This was our warning issued regarding the Cardinals last week, despite how popular of a pick they were:
"While the Titans have been atrocious, they are looking to fight back in Week 5 with the coaching staff feeling the pressure to change it up and perform. Arizona has lost two in a row, and has been relatively stagnant on offense in both matchups. Look for the Titans to come out firing, and they may surprise a few people.
With this being the heaviest selection option in most pools at over 30%, you don't want to go down with the masses. The line has fallen from +8.5 to +7.5 during the week, and there's 68% of the money vs. 46% of the total bets on Titans spread per our oddschecker+ Public Betting Splits tool, insinuating sharp action on the Titans. They may not win, but Cam Ward is fired up and will try to bounce back from the blanking at the hands of the Texans last week."
On the back of last week's result, a lot of those reasons are why the Cardinals are a great team to bet against this week. The Colts are red-hot and firing at 4-1 under Daniel Jones, one of the most unexpected starts in the league. Meanwhile, Arizona is reeling after that disastrous loss, and now Kyler Murray may be OUT with a foot sprain. If your league locks on Thursday night, you won't get the chance to wait for official word. But if you have the benefit of waiting, see how Murray trends through the weekend.
Jacoby Brissett is the Cardinals backup, and he would have a rough time against this Colts squad on the road. This spread would probably balloon from 7 to 10 if Murray is out, and that would make this the last best time to use the Colts. It's already their second-best usage
3. Los Angeles Rams (at Baltimore Ravens)
- Spread: Rams -7.5
- Moneyline: -380
- FairPlay AI Win Probability: 75%
- Mathematical Best Use Remaining: 4th out of 13
- Estimated Usage Percentage: 12%
The Rams are heading on the road to Baltimore in Week 6, and are somehow one of the most popular survivor selections. If someone told you that a month ago, you would be absolutely bewildered. But Lamar Jackson is still hurt, and the Rams are getting a -7.5 spread on the road after the Texans came in and absolutely obliterated the Ravens last week. And if the Texans' poor offense can do that, that who can't?
The Ravens were missing more than half of their defensive starters at one point, as well as Jackson at QB and some offensive line injuries. They will start to get a few pieces back, but it won't be good enough for this week. The Rams did just lose to a backup QB in the 49ers and Mac Jones last week, but they'll be fired up to avoid a similar fate against a reeling opponent. Note that this is only the 4th-best spot to use the Rams, and we'd recommend saving them for later like Week 9 vs. the Saints at home instead of risking an upset/wasting a strong team with future value.
4. Denver Broncos (at New York Jets) (Neutral - London)
- Spread: Broncos -7.5
- Moneyline: -395
- FairPlay AI Win Probability: 77%
- Mathematical Best Use Remaining: 3rd out of 13
- Estimated Usage Percentage: 6%
The Broncos just took down the Eagles in a statement win, and showed they can battle on the road with Super Bowl favorites. Bo Nix and co. staged a strong fourth quarter comeback, and will hope to carry the momentum to London this week against the lowly Jets. New York has yet to win a single game, and the Broncos don't want to be the first to allow it.
Based on how they dealt with the Bengals, they completely shut down a weak offense and put the hurt on them. Denver is best geared against mediocre offenses and will score just enough to beat most defenses. They don't need to put up 30+ points to win, and the same should be true this week. The only reason to give pause against the Jets is that this game is in London, and anything can happen abroad as team's change environments.
5. Philadelphia Eagles (vs. Las Vegas Raiders)
- Spread: Eagles -7
- Moneyline: -395
- FairPlay AI Win Probability: 70%
- Mathematical Best Use Remaining: 3rd out of 13
- Estimated Usage Percentage: 7%
Last but not least, the Eagles kick off Week 6 on Thursday Night Football at the Giants. While Philly should be able to handle business, we saw the Giants upset Justin Herbert and the Chargers two weeks ago, and Jaxson Dart is an unknown commodity. This isn't even the best time to use the Eagles, because you can get this exact same matchup at home in two weeks with them as a -13.5 favorite instead of just 7. We would recommend skipping this one for better options, as anything can happen on a short week, off a loss, in prime time against a divisional opponent on the road, just like the Rams last week even at home. Saquon and the Eagles should bounce back and win, but why risk it? There are better choices.
More NFL Odds
Affiliate Disclosure.
We are not a gambling or betting operator, but we receive a commission from these companies when we advertise their brands and refer customers to them (affiliate marketing). We provide information, odds information and links to websites of these companies. Some of the information made available on our site may be positioned as a result of a commission paid to us by a third party. We do not take or place bets/transactions and any information on Our Products is provided for entertainment purposes only.
