Rams vs. Jaguars Prediction, Betting Pick, Latest NFL Odds for NFL London Game
The Jacksonville Jaguars will host the Los Angeles Rams in London on Sunday morning. While it's usually a neutral site game for most teams, the Jags have built a strong London fanbase over the years, and find it closer to a home game. Can Trevor Lawrence and the Jags bounce back in a unique environment? Let's take a look at this Rams vs. Jaguars prediction and best betting pick.
OC Staff - October 18, 2025, 9:45 PM EDT
6 Minute ReadRams vs. Jaguars Prediction: Can Trevor Lawrence, Jags Bounce Back in Jags' Annual London Game?
The NFL’s international slate concludes this weekend as the Los Angeles Rams and Jacksonville Jaguars square off at Wembley Stadium on Sunday morning. Kickoff is set for 9:30 a.m. Eastern in what will be the third straight week of London action. The Rams enter the matchup as 3-point favorites in this neutral-site battle, looking to build on the momentum from their most recent win.
Los Angeles bounced back after a tough divisional loss to the 49ers by handling business on the road against a struggling Ravens team. Matthew Stafford and the offense looked sharp, and the defense stepped up in key spots to secure the victory. However, the Rams could be without star receiver Puka Nacua, who is nursing an ankle sprain and may be a game-time decision. His absence would leave a major hole in the passing game, forcing others like Cooper Kupp and Kyren Williams to shoulder more of the load.
Jacksonville, meanwhile, is looking to find some consistency after an up-and-down few weeks. The Jaguars pulled off a huge win against the Chiefs but couldn’t keep it going last week in a disappointing loss to the Seahawks. Trevor Lawrence continues to show flashes of brilliance, yet the offense has struggled to sustain drives against tougher defenses. As they make the long trip overseas, the Jaguars will be aiming to right the ship against a confident Rams team in what should be one of the more intriguing international matchups of the season.
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Rams vs. Jaguars Date, Time, and Where to Watch
- Date: Sunday, October 19, 2025
- Time: 9:30 AM ET
- How to Watch: NFL Network
Rams vs. Jaguars Odds
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Rams vs. Jaguars Prediction
The most compelling matchup pits Rams quarterback Matthew Stafford against the formidable Jacksonville pass defense. Stafford projects for 23/35 completions, 263.5 yards, and 0.6 interceptions. While Jacksonville's defense ranks an impressive 5th in QB Rating Allowed, implying tight coverage and disciplined play, a critical factor emerges: their pass rush ranks a lowly 28th in the league. This dynamic sets up a fascinating challenge for Stafford, who historically thrives when given time in the pocket.
Delving into the data, Stafford has a proven track record against elite pass defenses, posting an exceptional 102.6 Passer Rating over 9 games against top-10 units, averaging 252.9 passing yards per game with a remarkable 8.0 TD:INT ratio (16 TDs, 2 INTs). This suggests he's historically unfazed by stingy secondaries as long as he has the time to operate. The Jaguars' inability to consistently generate pressure (28th in sacks) could play directly into Stafford's strengths, allowing him to exploit their coverage with his precision and downfield accuracy. Given this significant historical performance against similar defensive quality and the Jaguars' pass-rush deficiency, our model identifies a strong opportunity: it found a substantial gap to exploit on the Over 263.5 Passing Yards prop for Stafford, noting a 10.8% Expected Value at 1.91 (-110) odds.
On the other side of the ball, Jaguars quarterback Trevor Lawrence projects for 22/35 completions, 232.1 yards, and 0.7 interceptions. Lawrence, a talented signal-caller with dual-threat capabilities, faces a significantly tougher assignment against the Los Angeles Rams' defense. The Rams boast a stout 7th-ranked pass defense in QB Rating Allowed, but more importantly, they bring a potent pass rush, ranking 4th in sacks. This combination creates a challenging environment for any quarterback.
Lawrence's historical splits against top-10 pass defenses paint a stark picture: over 4 games, he's managed a 76.5 Passer Rating, averaged 232.8 passing yards, and recorded a 1.0 TD:INT ratio (4 TDs, 4 INTs). These numbers suggest a struggle against high-caliber defensive units, particularly those that can generate consistent pressure. While Lawrence can extend plays with his legs, the provided data focuses on his passing game, which will be severely tested by the Rams' ability to both cover and rush the passer. This demanding matchup, with the Rams' defense excelling in both key areas, suggests the market is fairly priced for Lawrence's output, as our model found a negative EV (-0.8%) on the Over 232.1 Passing Yards prop at 1.91 (-110) odds.
Beyond the quarterback duel, the ground game presents another crucial battle, specifically involving Rams running back Kyren Williams. Williams, projected for 16.7 attempts and 69.5 rushing yards, has been a central figure in the Rams' offense. He will be facing a Jacksonville Jaguars run defense that ranks 16th in Rush Yds/Carry – a middling performance that indicates neither an impenetrable wall nor a sieve.
This matchup offers a solid opportunity for Williams to produce. If Matthew Stafford can capitalize on the Jaguars' weak pass rush and move the ball through the air, it will inevitably open up running lanes. The Jaguars' average run defense, contrasted with Williams' consistent production, creates a favorable scenario for the Rams to establish balance. Our model reflects this advantage, identifying a moderate edge with a 3.7% Expected Value on the Over 69.5 Rushing Yards prop for Williams at 1.91 (-110) odds. This suggests that the market might be slightly underestimating Williams' potential impact against a defense that isn't particularly strong against the run.
Ultimately, the most decisive factor in this intriguing cross-conference clash will be Matthew Stafford's ability to capitalize on Jacksonville's weak pass rush against their strong secondary. If Stafford can consistently dissect the Jaguars' 5th-ranked pass defense from a clean pocket, as his historical splits against top-tier units suggest he can, it will not only fuel the Rams' aerial attack but also open up the ground game for Kyren Williams. This particular matchup, highlighted by Stafford's elite performance against comparable defenses and the Jaguars' glaring deficiency in generating pressure, presents the most significant strategic advantage for either team and is likely to dictate the flow and outcome of the game.
Rams vs. Jaguars Pick
- Pick: Rams -3 (-110) Click here to get these best odds on DraftKings Sportsbook
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