Colts vs. Seahawks Prediction: Will Phillip Rivers Suit Up for Colts in Week 15 After Dramatic Comeback?

The NFL landscape sets the stage for a compelling clash this week, as the Indianapolis Colts, currently standing at 8-5 and #8 in the conference with a three-game losing streak and a concerning 2-4 road record, travel to face the surging Seattle Seahawks, who boast a 10-3 record, hold the #5 spot in the conference, and are riding a three-game winning streak with a solid 4-2 home performance.

This encounter pits a team desperately seeking to right the ship against a red-hot contender vying for playoff positioning, and the outcome will hinge on a few critical individual battles.

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Colts vs. Seahawks Date, Time, and Where to Watch

• Date: Sunday, December 14, 2025
• Time: 4:25 PM ET
• How to Watch: CBS

Colts vs. Seahawks Odds

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Colts vs. Seahawks Prediction

The most glaring mismatch on paper, and arguably the lynchpin of this contest, will be the Indianapolis Colts' young signal-caller, Riley Leonard, attempting to navigate the formidable Seattle Seahawks defense. Leonard’s projections for this game are modest at best, with an anticipated 10/18 for just 95.7 yards and 0.6 interceptions. His singular historical outing against a Top-10 Pass Defense paints an even bleaker picture: a dismal 60.3 Passer Rating, 145.0 passing yards, zero touchdowns, and one interception. He faces a Seattle defense that is nothing short of elite, ranking #3 in the league against the pass (by QB Rating Allowed) and #4 in pass rush (by sacks). This statistical disparity suggests Leonard will be under constant duress, struggling to find open receivers and likely facing a torrent of pressure from Seattle’s front.

For the Colts to have any chance, Leonard will need to defy his historical trends and deliver a performance far beyond expectations. Interestingly, even with these dire circumstances for Leonard, our model flags a substantial 35.4% Expected Value on Alec Pierce (WR1) to surpass his modest projection of 41.5 receiving yards at 1.91 (-110). This high-value opportunity suggests Pierce might serve as a crucial safety valve or benefit from late-game scenarios as the Colts potentially play from behind, providing a small glimmer of hope amidst a tough aerial forecast.

While Leonard faces an uphill battle through the air, the Colts' ground game, spearheaded by Jonathan Taylor, presents another critical matchup. Taylor is projected for a solid 20.4 attempts resulting in 80.9 rushing yards. However, he'll be running headfirst into one of the league's stingiest run defenses, with Seattle ranking #4 in the NFL against the run (by Rush Yds/Carry).

For the Colts to protect their young quarterback and maintain any semblance of offensive rhythm, Taylor's ability to consistently gain positive yardage will be paramount. Despite facing the league's 4th-ranked run defense, our model identifies a significant 5.4% Expected Value on Jonathan Taylor to surpass 81.0 rushing yards at 1.91 (-110). This indicates the market might be underestimating Taylor's ability to grind out yards even against a formidable front, offering the Colts a potential lifeline to control the clock and keep the ball out of Leonard's hands. His success here could be the Colts' most viable path to sustaining drives and keeping the game competitive.

On the other side of the ball, Seattle’s quarterback Sam Darnold enters the game with a projection of 20/29 for 232.4 yards and 0.6 interceptions. While Darnold is capable of putting up yardage, his historical splits against Top-10 Pass Defenses like the Colts (ranked #10 in QB Rating Allowed) reveal a noticeable pattern: in 7 such games, he averages a robust 270.9 passing yards but also sports an even 1.0 TD:INT ratio, throwing 10 touchdowns to 10 interceptions. The Colts' defense, while not as statistically dominant as Seattle's, is solid across the board, ranking #9 against the run and #10 against the pass, with a respectable #9 pass rush.

This matchup creates a compelling narrative: can the Colts' defense exploit Darnold's historical tendency to turn the ball over when pressured by quality defenses? If the Colts can generate pressure (Seahawks are also missing a significant EV prop for JSN, potentially indicating an average day for their passing game relative to his projection) and force Darnold into critical mistakes, it could provide the crucial turnovers needed to swing momentum and keep this game within reach, potentially creating short fields for their struggling offense.

Ultimately, while Jonathan Taylor's ability to defy the odds and run effectively against Seattle's stout front will be crucial for the Colts, the most decisive factor in this contest will undoubtedly be Riley Leonard's ability to withstand the relentless pressure from the Seahawks' elite defense. If the Colts' young quarterback falters as his historical data suggests he might, Seattle’s dominant pass defense and pass rush will likely dictate the flow of the game, making any upset bid a near impossibility.

Colts vs. Seahawks Pick

• Pick: Colts +14 (-110) Check out these best odds at BetMGM Sportsbook

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